Gut flora in health and disease

@article{Guarner2003GutFI,
  title={Gut flora in health and disease},
  author={Francisco Guarner and Juan Ramón Malagelada},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={512-519}
}

Figures from this paper

Enteric Flora in Health and Disease

It is important to underscore that the specialised lymphoid follicles of the gut mucosa are the major sites for induction and regulation of the immune system.

The Enteric Microbiota

Probiotics and prebiotics can be used to improve symbiosis between enteric microbiota and host, or correct states of dysbiosis, in a diverse and dynamic microbial ecosystem having an important impact on health and disease.

Impacts of Gut Bacteria on Human Health and Diseases

The roles and potential mechanisms of gut bacteria in human health and diseases are summarized and discussed.

Microbes in the gut: a digestable account of host-symbiont interactions.

The human bowel is host to a diverse group of bacteria with over 500 different bacterial species contributing to this diversity. Until recently these bacteria were regarded as residents without any

Gut Microbiota and Its Pathophysiology in Disease Paradigms

The physiological role of the Gut microbiota in maintaining a healthy state and the potential role played by disturbances of both the function and composition of the gut microbiota in determining important pathological conditions, such as irritable bowel syndrome, inflammatory bowel disease, metabolic syndrome, obesity, and cancer are focused on.

The intestinal flora in inflammatory bowel disease: normal or abnormal?

  • F. Guarner
  • Medicine
    Current opinion in gastroenterology
  • 2005
A balanced microbial environment would likely help in both prevention and control of inflammatory bowel disease and research is needed to identify microorganisms able to mediate immunoregulation in the gut mucosa.

The Human Gastric Microbiota in Health and Disease

The human body comprises of complex microbial ecosystems that have co-evolved with its host and play important roles in the maintenance of health and in the etiology and outcome of various disease

Linking the gut microbiota to human health

Development of novel gene sequencing technologies as well as availability of powerful bioinformatic analysis tools provide new insights into the composition and structure of the human gut microbiota.

Impacts of prebiotics on the immune system and inflammation.

Prebiotics are non-digestible food ingredients that are selectively fermented in the gut resulting in specific changes in the composition or activity of the gastrointestinal microbiota, thus conferring benefits upon host health.

Our gut microbiota: a long walk to homeostasis.

This review summarises factors involved in the regulation of a gut microbiome.
...

References

SHOWING 1-10 OF 133 REFERENCES

Molecular analysis of commensal host-microbial relationships in the intestine.

Coloring germ-free mice with Bacteroides thetaiotaomicron reveals that this commensal bacterium modulates expression of genes involved in several important intestinal functions, including nutrient absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intestinal maturation.

Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.

By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.

Functional food science and gastrointestinal physiology and function

The develop-ment of functional foods for the gut is in its infancy and will be successful only if more fundamental research is done on digestive physiology, the gut microflora, immune system and mucosal function.

Clinical significance of translocation.

It is hypothesized that multiple organ failure is more probably triggered by the combination of tissue damage and systemic endotoxaemia, and future therapeutic strategies could therefore focus more on binding endotoxin in the gut before the triggering event, for example before major surgery.

Ecological control of the gastrointestinal tract. The role of probiotic flora

Changes in food habits in Western countries that no doubt constitute stresses to the human body and that may predispose to inflammatory, infectious, ulcerative, degenerative, and neoplastic diseases include the following.

Protective role of probiotics and prebiotics in colon cancer.

Some of the newer studies showed that short-lived metabolite mixtures isolated from milk that was fermented with strains of Lactobacillus bulgaricus and Streptococcus thermophilus are more effective in deactivating etiologic risk factors of colon carcinogenesis than are cellular components of microorganisms.

Pre-, pro- and synbiotics

  • S. Bengmark
  • Medicine
    Current opinion in clinical nutrition and metabolic care
  • 2001
This review summarizes the present experience in various forms of diarrhoea, inflammatory bowel disease, and Helicobacter infections, in intensive care patients and in connection with extensive surgery.

Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis.

Data suggest that oral administration of probiotic B. longum exerts strong antitumor activity, as indicated by modulation of the intermediate biomarkers of colon cancer, and consequently reduced tumor outcome.

Nutritional impact of pre- and probiotics as protective gastrointestinal organisms.

The health benefits of pre- and probiotics have been the subject of increased research interests and the evidence both for and against their role in promoting health and treating disease is reviewed.
...