Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif.

@article{Shie2000GutenrichedKF,
  title={Gut-enriched Kr{\"u}ppel-like factor represses cyclin D1 promoter activity through Sp1 motif.},
  author={Jie Shie and Zhi Yi Chen and Ming Liang Fu and Richard George Pestell and Chi Chuan Tseng},
  journal={Nucleic acids research},
  year={2000},
  volume={28 15},
  pages={
          2969-76
        }
}
Cancer cells differ from normal cells in many characteristics including loss of differentiation and uninhibited cell proliferation. Recent studies have focused on the identification of factors contributing to cell growth and differentiation. Gut-enriched Krüppel-like factor (GKLF or KLF4) is a newly identified eukaryotic transcription factor and has been shown to play a role in regulating growth arrest. We have previously shown that GKLF mRNA levels were significantly decreased in colon cancer… CONTINUE READING

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