Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

@article{Caesar2012GutderivedLA,
  title={Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice},
  author={R. Caesar and C. S. Reigstad and Helene Kling B{\"a}ckhed and C. Reinhardt and Maria Ketonen and Gunnel {\"O}stergren Lund{\'e}n and Patrice D Cani and F. B{\"a}ckhed},
  journal={Gut},
  year={2012},
  volume={61},
  pages={1701 - 1707}
}
Background Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposity and are protected against diet-induced obesity, Objective To investigate whether the gut microbiota and, specifically, gut-derived lipopolysaccharide (LPS) promote WAT inflammation and contribute to impaired glucose metabolism. Method Macrophage composition and expression of proinflammatory and anti… Expand
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