Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

@article{VujkovicCvijin2015GutResidentLA,
  title={Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.},
  author={Ivan Vujkovic-Cvijin and Louise A. Swainson and Simon Chu and Alexandra M Ortiz and Clark A. Santee and Annalise Petriello and Richard M. Dunham and Douglas W. Fadrosh and Din L. Lin and Ali A. Faruqi and Yong Huang and Cristian Apetrei and Ivona Pandrea and Frederick M. Hecht and Christopher D. Pilcher and Nichole R. Klatt and Jason M. Brenchley and Susan V. Lynch and Joseph M McCune},
  journal={Cell reports},
  year={2015},
  volume={13 8},
  pages={1589-97}
}
Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (IDO 1). The role of gut microbes in this system remains unknown, and the SIV-infected rhesus macaque provides a well-described model for HIV-associated Th17 loss and mucosal immune disruption. We… CONTINUE READING
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