Gut REG3γ-Associated Lactobacillus Induces Anti-inflammatory Macrophages to Maintain Adipose Tissue Homeostasis

  title={Gut REG3$\gamma$-Associated Lactobacillus Induces Anti-inflammatory Macrophages to Maintain Adipose Tissue Homeostasis},
  author={Yugang Huang and Houbao Qi and Zhiqiang Zhang and Enlin Wang and Huan Yun and Hui Yan and Xiaomin Su and Yingquan Liu and Zenzen Tang and Yunhuan Gao and Wencong Shang and Jiang Zhou and Tianze Wang and Y. Che and Y. Zhang and Rongcun Yang},
  journal={Frontiers in Immunology},
Gut microbiota may not only affect composition of local immune cells but also affect systemic immune cells. However, it is not completely clear how gut microbiota modulate these immune systems. Here, we found that there exist expanded macrophage pools in huREG3γtgIEC mice. REG3γ-associated Lactobacillus, which is homology to Lactobacillus Taiwanese, could enlarge macrophage pools not only in the small intestinal lamina propria but also in the spleen and adipose tissues. STAT3-mediated signal(s… Expand
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