Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

@article{Chung2012GutIM,
  title={Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota},
  author={Hachung Chung and S. J. Pamp and Jonathan A. Hill and Neeraj K. Surana and Sanna M. Edelman and E. Troy and Nicola C. Reading and E. J. Villablanca and Sen Wang and J. Mora and Y. Umesaki and D. Mathis and C. Benoist and D. Relman and D. Kasper},
  journal={Cell},
  year={2012},
  volume={149},
  pages={1578-1593}
}
Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to determine whether small intestinal immune maturation depends on a coevolved host-specific microbiota. Gut bacterial numbers and phylum abundance were similar in MMb and HMb mice, but bacterial species differed, especially the Firmicutes. HMb mouse intestines had low levels of CD4(+) and CD8(+) T cells, few proliferating T… Expand
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