Gut–brain axis: how the microbiome influences anxiety and depression

@article{Foster2013GutbrainAH,
  title={Gut–brain axis: how the microbiome influences anxiety and depression},
  author={Jane A. Foster and Karen A Neufeld},
  journal={Trends in Neurosciences},
  year={2013},
  volume={36},
  pages={305-312}
}

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References

SHOWING 1-10 OF 93 REFERENCES

Normal gut microbiota modulates brain development and behavior

It is demonstrated that germ free (GF) mice display increased motor activity and reduced anxiety, compared with specific pathogen free (SPF) mice with a normal gut microbiota, suggesting that the microbial colonization process initiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.

Reduced anxiety‐like behavior and central neurochemical change in germ‐free mice

This work has shown that the presence of gut microbiota regulates the set point for hypothalamic‐pituitary‐adrenal (HPA) axis activity, and the role intestinal microbiota may play in communication between these two systems is increasing.

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

It is demonstrated that CNS neurotransmission can be profoundly disturbed by the absence of anormal gut microbiota and that this aberrant neurochemical, but not behavioural, profile is resistant to restoration of a normal gut flora in later life.

Bacterial infection causes stress-induced memory dysfunction in mice

Memory dysfunction occurs in infected mice exposed to acute stress, while in the germ-free setting memory is altered at baseline, suggesting the intestinal microbiota influences the ability to form memory.

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis.

The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.

The intestinal microbiota influences brain chemistry and behavior independently of the autonomic nervous system, gastrointestinal-specific neurotransmitters, or inflammation.

The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse

Electrophysiological properties of neurons in the myenteric plexus of the enteric nervous system in germ-free (GF) mice compared with specific pathogen‐free (SPF) control mice and adult germ‐free mice that have been conventionalized with intestinal bacteria are examined.

Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.

Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry, which can be normalized by inflammation-dependent and -independent mechanisms, neither of which requires the integrity of the vagus nerve.
...