Gustducin couples fatty acid receptors to GLP-1 release in colon.

  title={Gustducin couples fatty acid receptors to GLP-1 release in colon.},
  author={Yan Li and Zaza Kokrashvili and Bedřich Mosinger and Robert F Margolskee},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={304 6},
Sweet taste receptor subunits and α-gustducin found in enteroendocrine cells of the small intestine have been implicated in release of the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in response to glucose and noncaloric sweeteners. α-Gustducin has also been found in colon, although its function there is unclear. We examined expression of α-gustducin, GLP-1, and GIP throughout the intestine. The number of α-gustducin-expressing cells… CONTINUE READING