Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells.

@article{He2006GumMI,
  title={Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells.},
  author={Mei-lan He and Hui-qing Yuan and An-li Jiang and Ai Yu Gong and Wei-wen Chen and Peng-ju Zhang and Charles Y. F. Young and Jian-Ye Zhang},
  journal={Cancer},
  year={2006},
  volume={106 12},
  pages={2547-55}
}
Accumulating evidence suggests that the androgen receptor (AR) may play an important role in the development and progression of prostate cancer. To find new, useful compounds that effectively may attenuate the function of AR in prostate cancer cells, the authors investigated the effect of gum mastic, a natural resin, on AR activity. An androgen-responsive prostate cancer cell line LNCaP was used as a model for this study. Gene transfer, reverse transcriptase-polymerase chain reaction analysis… CONTINUE READING

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