Guinea pig hippocampal 5-HT(1E) receptors: a tool for selective drug development.

  title={Guinea pig hippocampal 5-HT(1E) receptors: a tool for selective drug development.},
  author={Michael T. Klein and Milt Teitler},
  journal={Journal of neurochemistry},
  volume={109 1},
Recent studies have indicated that the serotonin [5-hydroxytryptamine (5-HT)] 1E receptor, originally discovered in human brain tissue, is not expressed in rat or mouse brain. Thus, there have been few reports on 5-HT(1E) receptor drug development. However, expression of 5-HT(1E) receptor mRNA has been shown in guinea pig brain. To establish this species as an animal model for 5-HT(1E) drug development, we identified brain regions that exhibit 5-carboxyamidotryptamine, ritanserin, and LY344864… CONTINUE READING

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