Guilty until proven innocent: the case of NPC1 and cholesterol.

Abstract

Cholesterol accumulation in the endosomes and lysosomes of Niemann-Pick C (NPC) cells is considered to be the hallmark of this disorder, so the main focus of NPC research has revolved around cholesterol and its role in disease pathogenesis. However, recent data indicate that cholesterol is not the primary culprit in this human lipidosis. I propose a new… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.