Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis

@article{Berg2014GuillainBarrSP,
  title={Guillain–Barr{\'e} syndrome: pathogenesis, diagnosis, treatment and prognosis},
  author={Bianca van den Berg and Christa Walgaard and Judith Drenthen and Chris Fokke and Bart C. Jacobs and Pieter A. Doorn},
  journal={Nature Reviews Neurology},
  year={2014},
  volume={10},
  pages={469-482}
}
Guillain–Barré syndrome (GBS) is a potentially life-threatening postinfectious disease characterized by rapidly progressive, symmetrical weakness of the extremities. About 25% of patients develop respiratory insufficiency and many show signs of autonomic dysfunction. Diagnosis can usually be made on clinical grounds, but lumbar puncture and electrophysiological studies can help to substantiate the diagnosis and to differentiate demyelinating from axonal subtypes of GBS. Molecular mimicry of… 
Immunotherapy of Guillain-Barré syndrome
TLDR
Good circumstantial evidence exists for a pathogenic role for molecular mimicry in GBS pathogenesis, especially with its axonal forms, providing insights that could guide future immunotherapy, and the potential of leukocyte trafficking inhibitors as novel disease-specific immunotherapeutic drugs is highlighted.
The immunotherapy of Guillain-Barré syndrome
TLDR
This review offers a comprehensive view of the current treatment based upon the physiopathology of Guillain-Barré syndrome, finding new biomarkers and establishing algorithms of prediction of both the disease and its outcomes is warranted.
Severe Guillain-Barré syndrome
Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment
TLDR
The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9–17% of cases despite immunotherapy, but recent data point towards the role of ganglioside epitopes by immunohistochemical methods.
Diagnosis and management of Guillain–Barré syndrome in ten steps
TLDR
A globally applicable guideline for the diagnosis and management of Guillain–Barré syndrome is provided, including information on early recognition of the disease, prediction of clinical course and outcome, andmanagement of complications and sequelae.
The investigation of guillain-barre syndrome and prognosis
TLDR
In this study, age, respiratory failure, cranial nerve involvement and N/L ratio were found as related factors with short-term prognosis with Guillain-Barre Syndrome.
Guillain–Barré syndrome: pathophysiology, etiology, causes, and treatment
TLDR
The present literature review aims to broadly discuss GBS: etiology, pathophysiology and management in order to gain an understading of the existing studies that are relevant to this literature review.
Management of Guillain-Barré Syndrome
TLDR
A multidisciplinary approach to prevent and manage potential complications in rapidly progressing GBS is important to reduce morbidity and mortality.
An Overview of Guillain-Barré Syndrome
  • S. Esmail
  • Medicine
    Neurophysiology and Rehabilitation
  • 2019
TLDR
The aim of this article is to provide a practical overview of GBS, with particular emphasis on the clinical presentation, investigation and management of this important spectrum of neurological conditions.
Guillain-Barré Syndrome
TLDR
GBS is an acute/subacute-onset polyradiculoneuropathy typically presenting with sensory symptoms and weakness over several days, often leading to quadriparesis; a high level of suspicion is needed for early diagnosis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 170 REFERENCES
Treatment guidelines for Guillain–Barré Syndrome
TLDR
GBS is equally common in men and women and can occur at any age, but in western countries, GBS is common in the 5th decade but in India it occurs more commonly at a younger age.
Indicators of rapid clinical recovery in Guillain-Barré syndrome
TLDR
Among the axonal subgroup of patients with Guillain-Barré syndrome, preserved tendon reflexes, H influenzae infection, and the patient receiving immunoglobulin treatment may be indicators of rapid recovery.
Guillain–Barré syndrome associated with normal or exaggerated tendon reflexes
TLDR
DTRs could be normal or hyperexcitable during the entire clinical course in approximately 10% of GBS patients, and should be added in the diagnostic criteria to avoid delays in diagnosis and effective treatment to these patients.
Guillain‐Barré syndrome: subtypes and predictors of outcome from India
TLDR
AIDP is the commonest variant of GBS in this study and has better outcome compared to AMAN, and AIDP patients were older, more common in summer, had lesser peak disability, and better outcomes compared to those with AMAN.
Electrophysiological classification of guillain‐barré syndrome: Clinical associations and outcome
TLDR
Patients with pure motor GBS, enrolled in a trial comparing plasma exchange, intravenous immunoglobulin, and both treatments, were more likely than other GBS patients to have IgG antiganglioside GM1 antibodies and to have had preceding diarrhea but had a similar outcome.
[Imminent respiratory insufficiency in children resulting from Guillain-Barré syndrome].
TLDR
3 children, all boys, aged 22 months, 7 years and 4 years respectively, are presented with GBS in whom the diagnosis was missed upon admission, resulting in a failure to appreciate the risk of acute respiratory insufficiency.
Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria.
TLDR
The observed variability in the key diagnostic features of Guillain-Barré syndrome in the current cohort study, can be used to improve the sensitivity of the diagnostic criteria.
...
1
2
3
4
5
...