Guillain–Barré syndrome: a century of progress

  title={Guillain–Barr{\'e} syndrome: a century of progress},
  author={John Aaron Goodfellow and Hugh John Willison},
  journal={Nature Reviews Neurology},
In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell counts — novel findings that identified the disease we now know as Guillain–Barré syndrome (GBS). 100 years on, we have made great progress with the clinical and pathological characterization of GBS. Early clinicopathological and animal studies indicated that GBS was an immune-mediated demyelinating disorder, and that severe GBS could result in… CONTINUE READING
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