Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices.

@article{Millet2010GuidingND,
  title={Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices.},
  author={Larry J. Millet and Matthew E Stewart and Ralph G. Nuzzo and Martha L U Gillette},
  journal={Lab on a chip},
  year={2010},
  volume={10 12},
  pages={1525-35}
}
Wiring the nervous system relies on the interplay of intrinsic and extrinsic signaling molecules that control neurite extension, neuronal polarity, process maturation and experience-dependent refinement. Extrinsic signals establish and enrich neuron-neuron interactions during development. Understanding how such extrinsic cues direct neurons to establish neural connections in vitro will facilitate the development of organized neural networks for investigating the development and function of… CONTINUE READING