Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

@article{Allford2003GuidelinesOT,
  title={Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias},
  author={S. Allford and B. Hunt and P. Rose and S. Machin},
  journal={British Journal of Haematology},
  year={2003},
  volume={120}
}
Thrombotic thrombocytopenic purpura (TTP) was first described by Moschowitz (1924). The classic pentad of diagnostic features has been recognized for many years. However, several other syndromes are also characterized by similar features. These include haemolytic uraemic syndrome (HUS), eclampsia and the HELLP syndrome (haemolysis, elevated liver enzymes, low platelets). The concept has arisen that they might represent an overlapping spectrum of disease, although with varying pathophysiological… Expand
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