Guidelines for the selection of effective short-interfering RNA sequences for functional genomics.

@article{UiTei2007GuidelinesFT,
  title={Guidelines for the selection of effective short-interfering RNA sequences for functional genomics.},
  author={Kumiko Ui-Tei and Yuki Naito and Kaoru Saigo},
  journal={Methods in molecular biology},
  year={2007},
  volume={361},
  pages={201-16}
}
To avoid long-double-stranded-RNA-dependent interferon response, short-interfering RNAs (siRNAs) are widely used for RNA interference (RNAi) in mammalian cells. siRNA-based RNAi, however, may not be readily available for the large-scale gene silencing essential for systematic functional genomics, because only a limited fraction of siRNAs is capable of… CONTINUE READING

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