Guidelines for the prevention , diagnosis and management of nRTI-associated symptomatic hyperlactataemia and lactic acidosis

  • Published 2017

Abstract

Lactate is normally produced by all the body’s cells, as part of anaerobic metabolism. Certain cells (such as erythrocytes) lack mitochondria for aerobic respiration and are obligate lactate producers, while other cells will switch to predominant lactate production if the aerobic cycle is compromised, because of either a lack of available cellular oxygen or… (More)

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