Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization.

@article{Tuzun2015GuidelinesFS,
  title={Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization.},
  author={Erdem Tuzun and Sonia Berrih-Aknin and Talma Brenner and Linda L. Kusner and Rozen Le Panse and H. -S. Yang and Socrates J Tzartos and Premkumar Christadoss},
  journal={Experimental neurology},
  year={2015},
  volume={270},
  pages={11-7}
}
Myasthenia gravis (MG) is an autoimmune disorder characterized by generalized muscle weakness due to neuromuscular junction (NMJ) dysfunction brought by acetylcholine receptor (AChR) antibodies in most cases. Although steroids and other immunosuppressants are effectively used for treatment of MG, these medications often cause severe side effects and a complete remission cannot be obtained in many cases. For pre-clinical evaluation of more effective and less toxic treatment methods for MG, the… CONTINUE READING