Guidelines for radioiodinated MIBG scintigraphy in children

@article{Olivier2003GuidelinesFR,
  title={Guidelines for radioiodinated MIBG scintigraphy in children},
  author={Pierre Olivier and Paula Colarinha and Jure Fettich and Sibylle Fischer and J{\"o}rgen Fr{\"o}kier and Francesco Giammarile and Isky Gordon and Klaus Hahn and Levent Kabasakal and Mike Mann and Mercedes Mitjavila and Amy Piepsz and Ute Porn and Rune Sixt and Jeannette van Velzen},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2003},
  volume={30},
  pages={B45-B50},
  url={https://api.semanticscholar.org/CorpusID:20350450}
}
These guidelines on the use of radioiodinated 99mTc-MIBG scintigraphy in children, which summarise the views of the Paediatric Committee of the European Association of Nuclear Medicine, provide a…
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The Paediatric Task Group of the European Association of Nuclear Medicine has investigated the current situation and now suggests a method for standardization of administered amounts of radiopharmaceutical in paediatrics.

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The radioisotopes available for labeling of MIBG and related compounds, the dosimetry, metabolism and mechanisms of uptake and retention, and comparisons with other radiotracers available for imaging neuroblastomas are addressed.

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A number of important physiological areas of uptake in soft tissues can lead to false-positive interpretations of normal scans, such as the physiological upper thoracic uptake which has never been previously described.

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I-MIBG-scintigraphy makes it possible to define the nature of the tumour, particularly in cases with normal catecholamine levels; to establish how extensive the lesions are at the time of diagnosis; and to confirm complete remission.

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SPECT imaging compared to planar scanning can demonstrate a greater number of lesions, and seems to be indicated mainly in cases in which diagnostic assessment is difficult, such as small residual tumors or in the follow up of children no longer in therapy.

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In order to clarify some of the particularities and pitfalls of the MIBG thoracic scan, we report our experience with 5 children with Stage III or IV neuroblastoma who presented equivocal scans. The…