Guideline for the laboratory diagnosis of functional iron deficiency

@article{Thomas2013GuidelineFT,
  title={Guideline for the laboratory diagnosis of functional iron deficiency},
  author={D W Thomas and R F Hinchliffe and Carol J Briggs and Iain C Macdougall and Timothy James Littlewood and Ivor Cavill},
  journal={British Journal of Haematology},
  year={2013},
  volume={161}
}
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant… 
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TLDR
Future research areas are outlined including the role of Hepcidin and serum soluble transferrin receptor measurement, quantitative faecal immunochemical testing, alternative dosing regimens and the potential role of IV iron preparations.
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This analysis shows the benefit of using transferrin saturation in addition to ferritin, in the diagnosis of iron deficiency and even in first-line analysis for patients with chronic inflammatory diseases.
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References

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