Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.

  title={Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.},
  author={Ivor D. Hill and Martha H. Dirks and Gregory S. Liptak and Richard B. Colletti and Alessio Fasano and Stefano Guandalini and Edward J Hoffenberg and K{\'a}roly Horv{\'a}th and Joseph A. Murray and Mitchell Pivor and Ernest G. Seidman},
  journal={Journal of pediatric gastroenterology and nutrition},
  volume={40 1},
Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs in children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty and persistent iron deficiency anemia and in asymptomatic individuals with type 1 diabetes, Down syndrome, Turner syndrome, Williams syndrome, selective immunoglobulin (Ig)A deficiency and first degree… 

Management of celiac disease in childhood and adolescence: Unique challenges and strategies

  • I. Hill
  • Medicine
    Current treatment options in gastroenterology
  • 2006
The immunopathogenesis, epidemiology, and clinical manifestations of Celiac disease are discussed and a strategy of active case-finding using serological tests to identify those who require an intestinal biopsy for definitive diagnosis is outlined.

New Approaches to the Diagnosis and Management of Celiac Disease in Children

The clinical presentation of pediatric CD has changed in recent years and a number of patients are presenting with “atypical” and “silent” forms, and Physicians should be aware of these unique presentations and high-risk populations in order to avoid under-diagnosis of CD.


Alternative therapeutic strategies were developed to decrease the immunogenicity and to prevent the absorption of glutencontaining grains, together with strategies to limit T-cell migration or re-establish mucosal homeostasis.

Celiac disease: diagnosis and management.

Diagnosis is supported by a positive tissue transglutaminase serologic test but, in general, should be confirmed by a small bowel biopsy showing the characteristic histology associated with celiac disease.


Frequency of potential celiac disease in patients with refractory IDA was higher than control the subjects, and serologic screening for early detection and minimizing the complications of celiac Disease is recommended for this group.

Clinical guidelines on the diagnosis and treatment of celiac disease in Mexico

Celiac disease in children: A review of the literature

  • Y. Şahin
  • Medicine
    World journal of clinical pediatrics
  • 2021
The epidemiology, clinical findings, diagnostic tests, and treatment of celiac disease are discussed in the light of the latest literature in a review of the available literature.

Celiac disease: a review.

Diagnosing celiac disease requires a high degree of suspicion, followed by correct screening and a confirmatory test with an intestinal biopsy, which in most cases will bring a marked improvement of symptoms.



Prevalence and clinical picture of celiac disease in Turner syndrome.

The subclinical picture in 60% of the cases, the diagnostic delay, and the incidence of other autoimmune disorders suggest that routine screening of CD in TS is indicated, confirming the high prevalence of celiac disease in a large series of TS patients.

Prevalence and diagnosis of celiac disease in IgA-deficient children.

Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease: an Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and "Club del Tenue" Working Groups on Coeliac Disease.

Serum IgA should be measured in order to be able to interpret negative results for IgA anti-gliadin antibodies and anti-endomysial antibodies in patients being screened for CD, since some patients with CD and SIgAD may be negative for IgG anti- gliadin antibody levels.

Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy.

Detection of gliadin IgA by ELISA and to a lesser extent the endomysial IgA should allow better selection of patients for jejunal biopsy and thus make diagnosing coeliac disease simpler and more efficient.

Celiac Disease: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition

Treatment of Celiac disease requires lifelong adherence to a diet that strictly eliminates products containing wheat, rye, and barley and complete recovery of the small intestinal damage can be expected with reversal of nutritional deficits and resolution of symptoms.

Celiac disease in relation to immunologic serum markers, trace elements, and HLA-DR and DQ antigens in Swedish children with Down syndrome.

The results show that determination of EMA is more useful as a screening test for celiac disease and for follow-up than is AGA in children with Down syndrome, and confirms that Celiac disease is overrepresented among Swedish children with down syndrome.

High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase.

It is confirmed that CD is as prevalent in the pediatric type 1 diabetic population in British Columbia as it is in Europe and suggests that tTG serology may also be useful in monitoring response and compliance with a gluten-free diet.

Coeliac disease in children and adolescents with IDDM: clinical characteristics and response to gluten‐free diet

Serological screening for coeliac disease using the IgA endomysial test is effective, although the therapeutic benefit of dietary therapy in asymptomatic cases remains uncertain.

Prevalence of Celiac disease among children in Finland.

The presence of serum tissue transglutaminase and endomysial autoantibodies is predictive of small-bowel abnormalities indicative of celiac disease and there is a good correlation betweenAutoantibody positivity and specific HLA haplotypes.