Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction.

@article{Behfar2010GuidedCE,
  title={Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction.},
  author={Atta Behfar and Satsuki Yamada and Ruben J Crespo-Diaz and Jonathan J Nesbitt and Lois Rowe and Carmen Perez-Terzic and Vinciane Gaussin and Christian Homsy and Jozef Bartunek and Andre Terzic},
  journal={Journal of the American College of Cardiology},
  year={2010},
  volume={56 9},
  pages={
          721-34
        }
}
OBJECTIVES The goal of this study was to guide bone marrow-derived human mesenchymal stem cells (hMSCs) into a cardiac progenitor phenotype and assess therapeutic benefit in chronic myocardial infarction. BACKGROUND Adult stem cells, delivered in their naïve state, demonstrate a limited benefit in patients with ischemic heart disease. Pre-emptive lineage pre-specification may optimize therapeutic outcome. METHODS hMSC were harvested from a coronary artery disease patient cohort. A… CONTINUE READING

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