Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments

@article{Stewart2017GuidanceTM,
  title={Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments},
  author={D. Stewart and A. Mair and M. Wilson and P. Kardas and Paweł Lewek and A. Alonso and J. McIntosh and K. Maclure},
  journal={Expert Opinion on Drug Safety},
  year={2017},
  volume={16},
  pages={203 - 213}
}
ABSTRACT Introduction: Single disease state led evidence-based guidelines do not provide sufficient coverage of issues of multimorbidities, with the cumulative impact of recommendations often resulting in overwhelming medicines burden. Inappropriate polypharmacy increases the likelihood of adverse drug events, drug interactions and non-adherence. Areas covered: A detailed description of a pan-European initiative, ‘Stimulating Innovation Management of Polypharmacy and Adherence in the Elderly… Expand
Interventions to improve the appropriate use of polypharmacy for older people.
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It is uncertain whether pharmaceutical care reduces the proportion of patients with one or more PIMs, or improves medication appropriateness, and the overall certainty of evidence for each pooled outcome ranged from low to very low. Expand
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Multiple factors across the full range of change management and implementation principles were involved in the implementation and sustainability of medication reviews in older patients by clinical pharmacists in Region Uppsala, Sweden. Expand
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A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people
TLDR
Consensus was obtained amongst key EU strategists around many aspects of polypharmacy management in older people and no consensus was achieved in relation to statements relating to the need to alter legislation in areas of healthcare delivery, remuneration and practitioner scope of practice. Expand
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TLDR
Polypharmacy and PIMs were prevalent in older adults with CKD; pharmacist-led geriatric MMS improved the quality of medication use in this population. Expand
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TLDR
This study found polypharmacy present in over one fifth of Polish society, with peak in the elderly, and the results lay the foundations for future interventions focused on reducing the scope of this problem in Poland. Expand
Extreme polypharmacy: The need to mint a new term
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Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe.
TLDR
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It is uncertain whether pharmaceutical care reduces the proportion of patients with one or more PIMs, or improves medication appropriateness, and the overall certainty of evidence for each pooled outcome ranged from low to very low. Expand
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