Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.

@article{Kaatz2012GuidanceOT,
  title={Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.},
  author={Scott Kaatz and Peter A Kouides and David Antol{\'i}n Garc{\'i}a and Alex C Spyropolous and Mark Crowther and James Demetrios Douketis and Anthony K. C. Chan and Andra H. James and Stephan Moll and Thomas L Ortel and Elizabeth Merrill Van Cott and J. I. Ansell},
  journal={American journal of hematology},
  year={2012},
  volume={87 Suppl 1},
  pages={
          S141-5
        }
}
The new oral anticoagulants dabigatran, rivaroxaban and apixaban have advantages over warfarin which include no need for laboratory monitoring, less drug-drug interactions and less food-drug interactions. However, there is no established antidote for patients who are bleeding or require emergent surgery and there is a paucity of evidence to guide the clinical care during these situations. Members of thrombosis and anticoagulation groups participating in the Thrombosis and Hemostasis Summit of… CONTINUE READING
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