Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling

Abstract

Cardiac chamber formation involves dynamic changes in myocardial organization, including trabeculation and expansion of the compact layer. The positional cues that regulate myocardial patterning, however, remain unclear. Through ligation of the Plexin-A1 receptor, the transmembrane-type semaphorin Sema6D regulates endocardial cell migration. Here, we… (More)
DOI: 10.1038/ncb1193

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