Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions.

@article{Nichol2016GuidanceOA,
  title={Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions.},
  author={Robert H Nichol and Kate M Hagen and Derek C. Lumbard and Erik W. Dent and Timothy M Gomez},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 7},
  pages={2267-82}
}
UNLABELLED Growth cones interact with the extracellular matrix (ECM) through integrin receptors at adhesion sites termed point contacts. Point contact adhesions link ECM proteins to the actin cytoskeleton through numerous adaptor and signaling proteins. One presumed function of growth cone point contacts is to restrain or "clutch" myosin-II-based filamentous actin (F-actin) retrograde flow (RF) to promote leading edge membrane protrusion. In motile non-neuronal cells, myosin-II binds and exerts… CONTINUE READING
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