Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in Absorption

@article{Johnson1996GuidanceIT,
  title={Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in Absorption},
  author={Kevin C. Johnson and Archie C. Swindell},
  journal={Pharmaceutical Research},
  year={1996},
  volume={13},
  pages={1795-1798}
}
Purpose. To provide guidance in setting particle size specifications for poorly soluble drugs to minimize variability in absorption. Methods. A previously reported computer method was used to simulate the percent of dose absorbed as a function of solubility, absorption rate constant, dose, and particle size. Results. The simulated percent of dose absorbed was tabulated over a realistic range of solubilities, absorption rate constants, and doses using drug particle sizes that might be typically… CONTINUE READING