Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists.

@article{Youn2009GuggulsteroneST,
  title={Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists.},
  author={Hyung-sun Youn and Sang-Il Ahn and Boo-yong Lee},
  journal={International immunopharmacology},
  year={2009},
  volume={9 1},
  pages={108-12}
}
Toll-like receptors (TLRs) are vital in the induction of innate immune responses. The microbial components trigger the activation of the myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent downstream TLR signaling pathways. Guggulsterone, which has been used for centuries to treat many chronic diseases, inhibits the MyD88-dependent pathway by inhibiting the activity of inhibitor-kappaB kinase. However, it is… CONTINUE READING

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