Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress.

@article{Moon2011GuggulsteroneSH,
  title={Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress.},
  author={Dong-Oh Moon and Sung-Yong Park and Young Hyun Choi and Jong Seog Ahn and Gi-young Kim},
  journal={Biochemical pharmacology},
  year={2011},
  volume={82 11},
  pages={1641-50}
}
Guggulsterone (GGS) has anti-tumor and anti-angiogenesis potential by suppressing nuclear factor-κB and STAT3 activity. Although GGS has been suggested as a potential therapeutic agent for treating various cancers, the underlying molecular mechanisms are unknown. Therefore, we investigated whether GGS sensitizes hepatocellular carcinoma cells (HCC) to apoptosis mediated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). The apoptotic mechanism induced by treatment with a GGS… CONTINUE READING
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Endoplasmic reticulum: stress, signaling and apoptosis

  • SG Hussain, Ramaiah KVA
  • Curr Sci 2007;93:1684–96
  • 2007
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