Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-κB and STAT3 pathways in head and neck cancer cells.

@article{Macha2011GuggulsteroneI,
  title={Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-κB and STAT3 pathways in head and neck cancer cells.},
  author={Muzafar Ahmad Macha and Ajay Matta and Shyam Singh Chauhan and K. W. Michael Siu and Ranju Ralhan},
  journal={Carcinogenesis},
  year={2011},
  volume={32 3},
  pages={368-80}
}
Understanding the molecular pathways perturbed in smokeless tobacco- (ST) associated head and neck squamous cell carcinoma (HNSCC) is critical for identifying novel complementary agents for effective disease management. Activation of nuclear factor-kappaB (NF-κB) and cyclooxygenase-2 (COX-2) was reported in ST-associated HNSCC by us [Sawhney,M. et al. (2007… CONTINUE READING