Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition

@inproceedings{Ariumi2016GuardianOT,
  title={Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition},
  author={Yasuo Ariumi},
  booktitle={Front. Chem.},
  year={2016}
}
Long interspersed element type 1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome, encoding a newly identified ORF0 with unknown function, ORF1p with RNA-binding activity and ORF2p with endonuclease and reverse transcriptase activities required for L1 retrotransposition. L1 utilizes an endonuclease (EN) to insert L1 cDNA into target DNA, which induces DNA double-strand breaks (DSBs). The ataxia-telangiectasia mutated (ATM) is activated by DSBs and subsequently… CONTINUE READING
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