Guarana (Paullinia cupana Mart.) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells.

@article{Bittencourt2014GuaranaC,
  title={Guarana (Paullinia cupana Mart.) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells.},
  author={Leonardo da Silva Bittencourt and Fares Zeid{\'a}n-Chuli{\'a} and Francini Kiyono Jorge Yatsu and Carlos Eduardo Schnorr and Karla Suzana Moresco and Eduardo Ant{\^o}nio Kolling and Daniel Pens Gelain and Valqu{\'i}ria Linck Bassani and Jos{\'e} Cl{\'a}udio Fonseca Moreira},
  journal={Phytotherapy research : PTR},
  year={2014},
  volume={28 11},
  pages={1615-24}
}
Advanced glycation end-products (AGEs) are considered potent molecules capable of promoting neuronal cell death and participating in the development of neurodegenerative disorders such as Alzheimer's disease (AD). Previous studies have shown that AGEs exacerbate β-amyloid (Aβ) aggregation and AGE-related cross-links are also detected in senile plaques. Acrolein (ACR) is an α, β-unsaturated aldehyde found in the environment and thermally processed foods, which can additionally be generated… CONTINUE READING
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