Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function.

@article{Hamad2003GuanylylCN,
  title={Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function.},
  author={Ahmed M. Hamad and Andrew Clayton and Baharul B Islam and Alan J. Knox},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 5},
  pages={L973-83}
}
Airway smooth muscle (ASM) plays an important role in asthma pathophysiology through its contractile and proliferative functions. The cyclic nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) are second messengers capable of mediating the effects of a variety of drugs and hormones. There is a large body of evidence to support the hypothesis that cAMP is a mediator of the ASM's relaxant effects of drugs, such as beta2-adrenoceptor agonists, in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 130 references

Compared effects of natriuretic peptides on ovalbumin-induced asthmatic model

  • H Ohbayashi, H Suiti, K. Takagi
  • Eur J Pharmacol
  • 1998
Highly Influential
11 Excerpts

Similar Papers

Loading similar papers…