Guanylyl cyclase receptors and guanylin-like peptides in reptilian intestine.

  title={Guanylyl cyclase receptors and guanylin-like peptides in reptilian intestine.},
  author={William J. Krause and Ronald H. Freeman and Sammy L. Eber and F. Kent Hamra and Mark G. Currie and Leonard Ralph Forte},
  journal={General and comparative endocrinology},
  volume={107 2},
Receptors for guanylin and uroguanylin were identified on the mucosal surface of enterocytes lining the intestine of the bobtail skink (Tiliqua rugosa), king's skink (Egernia kingii), and knight anole (Anolis equestris) by receptor autoradiography using 125I-ST (Escherichia coli heat-stable enterotoxin) as the radioligand. Specific, high-affinity binding of 125I-ST to receptors was found on the microvillus border of enterocytes and little or no specific binding of 125I-ST was observed in other… CONTINUE READING


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