Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.

@article{Li2007GuanylylCC,
  title={Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.},
  author={Peng P. Li and Stephanie Schulz and Alessandro Bombonati and Juan Pablo Palazzo and Terry Hyslop and Yihuan Xu and Amy A. Baran and Linda D Siracusa and Giovanni Mario Pitari and Scott A. Waldman},
  journal={Gastroenterology},
  year={2007},
  volume={133 2},
  pages={599-607}
}
BACKGROUND AND AIMS The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin, endogenous ligands for guanylyl cyclase C (GCC). Beyond intestinal fluid balance, GCC mediates diarrhea induced by bacterial enterotoxins, and an inverse relationship exists between enterotoxigenic Escherichia coli infections producing the exogenous GCC ligand ST and colorectal cancer worldwide. However, the role of GCC in neoplasia remains obscure. METHODS Intestinal… CONTINUE READING

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