Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity.

@article{Snook2008GuanylylCC,
  title={Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity.},
  author={Adam E Snook and Benjamin J Stafford and Peng Li and Gene S. Tan and Lan Huang and Ruth C. Birbe and Stephanie Schulz and Matthias J Schnell and Mathew Thakur and Jay L. Rothstein and Laurence Eisenlohr and Scott A. Waldman},
  journal={Journal of the National Cancer Institute},
  year={2008},
  volume={100 13},
  pages={950-61}
}
BACKGROUND One of the greatest impediments to cancer immunotherapy is the paucity of antigens that are tumor specific, sufficiently immunogenic, and shared among patients. Mucosa-restricted antigens that are expressed by tumor cells represent a novel class of vaccine targets that are characterized by immunologic privilege, which limits systemic tolerance to those antigens, and immunologic partitioning, which shields mucosae from systemic autoimmune responses. Here we defined the immunogenicity… CONTINUE READING
20 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

CX 3 CR 1mediated dendritic cell access to the intestinal lumen and bacterial clearance

  • JH Niess, S Brand, X Gu
  • Science
  • 2005

Similar Papers

Loading similar papers…