Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target.

  title={Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target.},
  author={Jieru Egeria Lin and Peng P. Li and Giovanni Mario Pitari and Stephanie Schulz and Scott A. Waldman},
  journal={Future oncology},
  volume={5 4},
Colorectal cancer is one of the leading causes of tumor-related morbidity and mortality worldwide. While mechanisms underlying this disease have been elucidated over the past two decades, these molecular insights have failed to translate into efficacious therapy. The oncogenomic view of cancer suggests that terminal transformation reflects the sequential corruption of signal transduction circuits regulating key homeostatic mechanisms, whose multiplicity underlies the therapeutic resistance of… CONTINUE READING


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