Guanylate-binding protein 1 participates in cellular antiviral response to dengue virus

@inproceedings{Pan2012GuanylatebindingP1,
  title={Guanylate-binding protein 1 participates in cellular antiviral response to dengue virus},
  author={Wen X Pan and Xiangyang Zuo and Tingting Feng and Xiaohong Shi and Jianfeng Dai},
  booktitle={Virology Journal},
  year={2012}
}
Dengue virus (DENV), the causative agent of human Dengue hemorrhagic fever, is a mosquito-borne virus found in tropical and sub-tropical regions around the world. Vaccines against DENV are currently unavailable. Guanylate-binding protein 1 (GBP1) is one of the Interferon (IFN) stimulated genes (ISGs) and has been shown important for host immune defense against various pathogens. However, the role of GBP1 during DENV infection remains unclarified. In this study, we evaluated the relevance of… CONTINUE READING