Guanylate Cyclase-Activating Protein-2 Undergoes Structural Changes upon Binding to Detergent Micelles and Bicelles.

@article{Margeti2014GuanylateCP,
  title={Guanylate Cyclase-Activating Protein-2 Undergoes Structural Changes upon Binding to Detergent Micelles and Bicelles.},
  author={Aleksandra Margeti{\'c} and David P Nannemann and Jens Meiler and Daniel Huster and Stephan Theisgen},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1838 11},
  pages={
          2767-77
        }
}
GCAPs are neuronal Ca(2+)-sensors playing a central role in light adaptation. GCAPs are N-terminally myristoylated membrane-associated proteins. Although, the myristoylation of GCAPs plays an important role in light adaptation its structural and physiological roles are not yet clearly understood. The crystal-structure of GCAP-1 shows the myristoyl moiety inside the hydrophobic core of the protein, stabilizing the protein structure; but (2)H-solid-state NMR investigations on the deuterated… CONTINUE READING

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