Guanosine triphosphate fulfills a complete and specific nucleotide requirement for luteinizing hormone-induced desensitization of pig ovarian adenylyl cyclase.


Homologous desensitization of the ovarian LH-sensitive adenylyl cyclase in cell-free systems is known to be dependent on micromolar concentrations of GTP. In this study, we sought to determine whether the nucleotide requirement of GTP for desensitization is complete and specific. LH-dependent desensitization of the adenylyl cyclase of pig ovarian follicular… (More)


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