Guanosine triphosphate cyclohydrolase activity in rat tissues.

  title={Guanosine triphosphate cyclohydrolase activity in rat tissues.},
  author={Zina Bellahsene and Jean Louis Dhondt and J. P. Farriaux},
  journal={The Biochemical journal},
  volume={217 1},
  • Zina Bellahsene, Jean Louis Dhondt, J. P. Farriaux
  • Published in The Biochemical journal 1984
  • Chemistry, Medicine
  • The GTP cyclohydrolase activity of rat tissues has been studied by means of the measurement of formic acid release and neopterin synthesis from GTP. After gel filtration of a 45%-satd.-(NH4)2SO4 fraction of liver homogenates, three enzyme fractions were separated and named A1, A2 and A3 according to the order of their elution. Fractions A1 and A3 displayed an 8-formyl-GTP deformylase activity; no proof of cyclized product has yet been established. This activity was heat-labile and required Mg2… CONTINUE READING

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