Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region

@inproceedings{Tapscott2018GuanosineTR,
  title={Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region},
  author={Timothy Tapscott and Ju-Sim Kim and M. A. Crawford and Liam F. Fitzsimmons and Lin Liu and Jessica Jones-Carson and Andr{\'e}s V{\'a}zquez-Torres},
  booktitle={Scientific Reports},
  year={2018}
}
The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the −10 promoter element and the transcription start site of the regulatory gene ssrA plays a distinct role… CONTINUE READING