Guanosine promotes proliferation of neural stem cells through cAMP-CREB pathway.

@article{Su2013GuanosinePP,
  title={Guanosine promotes proliferation of neural stem cells through cAMP-CREB pathway.},
  author={Caixin Su and Peixiang Wang and Cai Hong Jiang and Patrizia Ballerini and Francesco Caciagli and Michel Piers Rathbone and Shucui Jiang},
  journal={Journal of biological regulators and homeostatic agents},
  year={2013},
  volume={27 3},
  pages={673-80}
}
In previous studies, we have found that extracellular guanosine can stimulate endogenous progenitor/stem cell proliferation in the spinal cord following chronic injury and in the subventricular zone of the brains of rats afflicted with Parkinson's Disease. In this study, using neural stem cells isolated from one-day old rats, we found that guanosine could stimulate neural stem cell proliferation, and that the proliferation was not due to the guanosine metabolism mechanism since guanine, which… CONTINUE READING