Guanosine promotes myelination and functional recovery in chronic spinal injury.

Abstract

Functional loss after spinal cord injury (SCI) is caused, in part, by demyelination of axons surviving the trauma. Administration of guanosine (8 mg/kg/day, i.p.) for 7 consecutive days, starting 5 weeks after moderate SCI in rats, improved locomotor function and spinal cord remyelination. Myelinogenesis was associated with an increase in the number of mature oligodendrocytes detected in guanosine-treated spinal cord sections in comparison with controls. These data indicate that guanosine-induced remyelination resulted, at least in part, from activation of endogenous oligodendrocyte lineage cells. These findings may have significant implications for chronic demyelinating diseases.

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@article{Jiang2003GuanosinePM, title={Guanosine promotes myelination and functional recovery in chronic spinal injury.}, author={Shucui Jiang and Mohammad Nasim Imtiaz Khan and Yao Lu and Jian Wang and Josef Buttigieg and Eva S. Werstiuk and Renata Ciccarelli and Francesco Caciagli and Michel Piers Rathbone}, journal={Neuroreport}, year={2003}, volume={14 18}, pages={2463-7} }