Guanosine metabolism in adult rat cardiac myocytes: ribose-enhanced GTP synthesis from extracellular guanosine

@article{Geisbuhler2004GuanosineMI,
  title={Guanosine metabolism in adult rat cardiac myocytes: ribose-enhanced GTP synthesis from extracellular guanosine},
  author={T. Geisbuhler and M. Rovetto},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={419},
  pages={160-165}
}
The metabolic fate of transported guanosine was examined in adult rat cardiac myocytes. Freshly isolated cells were incubated with 10 μM or 100 μM [3H]guanosine and the nucleotide products extracted and examined for radiolabel distribution. The data presented show significant incorporation of guanosine into the 5′-nucleotide pool, and a marked stimulation of that incorporation by ribose. An average of 233 pmol/mg cell protein extracellular guanosine was incorporated into the cellular 5… Expand
5 Citations
Anoxia inhibits guanosine salvage in cardiac myocytes
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Compartmentalization of non-adenine nucleotides in anoxic cardiac myocytes
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