Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: new evidence for a putative novel function of uncoupling proteins as superoxide anion transporters.

Abstract

In this report, we show new experimental evidence that, in mouse brain mitochondria, uncoupling protein-2 (UCP2) can be involved in superoxide (O(2)(·-)) removal from the mitochondrial matrix. We found that the effect of guanosine 5'-diphosphate (GDP) on the rate of reactive oxygen species (ROS) release from brain mitochondria of UCP2 knockout mice was less… (More)
DOI: 10.1016/j.bbrc.2012.10.025

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@article{Suski2012GuanosineDE, title={Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: new evidence for a putative novel function of uncoupling proteins as superoxide anion transporters.}, author={Jan M. Suski and Peter Sch{\"o}nfeld and Massimo Bonora and Irina G Shabalina and Paolo Pinton and Mariusz R Wieckowski}, journal={Biochemical and biophysical research communications}, year={2012}, volume={428 2}, pages={234-8} }