Guanosine and its modified derivatives are endogenous ligands for TLR7.

@article{Shibata2016GuanosineAI,
  title={Guanosine and its modified derivatives are endogenous ligands for TLR7.},
  author={Takuma Shibata and Umeharu Ohto and Shosaku Nomura and Kayoko Nishimura Kibata and Yuji Motoi and Yan Zhang and Yusuke Murakami and Ryutaro Fukui and Tatsushi Ishimoto and Shigetoshi Sano and Tomoki Ito and Toshiyuki Shimizu and Kensuke Miyake},
  journal={International immunology},
  year={2016},
  volume={28 5},
  pages={211-22}
}
Toll-like receptor (TLR) 7and 8 were considered to recognize single-strand RNA (ssRNA) from viruses. Although these receptors also respond to synthetic small chemical ligands, such as CL075 and R848, it remains to be determined whether these receptors sense natural small molecules or not. In the structure of human TLR8 (huTLR8) with ssRNA, there are two ligand-binding sites: one binds a uridine and the other binds an oligoribonucleotide (ORN). This finding demonstrates that huTLR8 recognizes… CONTINUE READING
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