Guanosine Enhances Glutamate Uptake in Brain Cortical Slices at Normal and Excitotoxic Conditions

  title={Guanosine Enhances Glutamate Uptake in Brain Cortical Slices at Normal and Excitotoxic Conditions},
  author={Marcos Em{\'i}lio Frizzo and Diogo Rizzato Lara and Alexandre de Souza Prokopiuk and Carmen Regla Vargas and Christianne Gazzana Salbego and Moacir Wajner and Diogo Onofre Souza},
  journal={Cellular and Molecular Neurobiology},
1. The effect of guanosine on L-[2,3-3H]glutamate uptake was investigated in brain cortical slices under normal or oxygen–glucose deprivation (OGD) conditions. 2. In slices exposed to physiological conditions, guanosine (1–100 μM) stimulated glutamate uptake (up to 100%) in a concentration-dependent manner when a high (100 μM) but not a low (1 μM) concentration of glutamate was used. 3. In slices submitted to OGD, guanosine 1 and 100 μM also increased 100 μM glutamate uptake (38 and 70… CONTINUE READING


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