Guanine tetrad and palindromic sequence play critical roles in the RNA dimerization of bovine foamy virus

@article{Yu2007GuanineTA,
  title={Guanine tetrad and palindromic sequence play critical roles in the RNA dimerization of bovine foamy virus},
  author={Hanshou Yu and T. Li and Wentao Qiao and Qing Chao Chen and Yun-qi Geng},
  journal={Archives of Virology},
  year={2007},
  volume={152},
  pages={2159-2167}
}
Retroviruses are unique in having a diploid genome. However, the RNA sequences and structures that link the two RNA molecules are different. To identify the dimer linkage site of bovine foamy virus (BFV), complementary DNAs were used to interfere with RNA dimerization of BFV. We found that two sites, designated SI and SII, within a 53-base RNA fragment, were essential for BFV dimerization in vitro. SI consists of a potential guanine tetrad (GGGGC), which overlaps the primer binding site, while… CONTINUE READING