Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo.

@article{Baron1989GuanineNA,
  title={Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo.},
  author={Bruce Baron and Mark W. Dudley and Donald R McCarty and Frank J. Miller and Ian J. Reynolds and Christopher J. Schmidt},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={250 1},
  pages={162-9}
}
Guanine nucleotides were shown to alter N-methyl-d-aspartate (NMDA) receptor-effector coupling by competitive antagonism at the glutamate binding site, rather than via interaction with an intracellularly located GTP-binding protein. Thus, in contrast to known G-protein linked receptors, micromolar concentrations of guanine nucleotides and their analogs decreased both agonist [( 3H]glutamate) and antagonist [( 3H]-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid binding to the NMDA receptor… CONTINUE READING
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